Another area where knowing the limits (or the number or infinity of variables that may matter) is crucial. I like to look at the weather reports that discuss not just the percent chance of this or that, but also the degree of certainty the meteorologists have and why they have that degree of certainty, which always includes noting how other possible factors may come in to play affecting a different outcome. In contrast, the simulations you're talking about above are the type that limit the variables and can be investigated carrying from one context to another (as in drug testing) or predicting the utility of a new tool (as in designing a new mass spectrometer).
Another area where knowing the limits (or the number or infinity of variables that may matter) is crucial. I like to look at the weather reports that discuss not just the percent chance of this or that, but also the degree of certainty the meteorologists have and why they have that degree of certainty, which always includes noting how other possible factors may come in to play affecting a different outcome. In contrast, the simulations you're talking about above are the type that limit the variables and can be investigated carrying from one context to another (as in drug testing) or predicting the utility of a new tool (as in designing a new mass spectrometer).